I'm writing this review as an observer. Sometimes an observer notices things the patient doesn't realize are going on. My adult daughter has suffered with treatment-resistant depression for 16 years, and really much longer than that.She's taken antidepressants along with therapy though those years with minimal to no results. Out of exhaustion and despair she has reached the point of considering and planning suicide several times, but thankfully was always interrupted.When we learned of Texas Ketamine Specialists she really wanted to try ketamine. Her veins are hard to reach, and the fact that an anesthesiologist was available to start and maintain the IV made this the perfect practice. We'd heard it was important for a psychiatrist to monitor the patient's response to the ketamine, and felt this was the perfect combination of skills. After the first infusion, she didn't feel much different, until 24 hours later, and her listlessness began to be replaced with initiative...she felt like folding clothes. Her emotions weren't very changed, but her energy was improving. The next day was her second infusion. As we drove home she began to feel a lightening in her mood. Not dramatic at first, but it continued to improve every day. By the next week she had the energy to shop, run errands, and was laughing again and having fun. This course continued to increase and continue throughout the infusion series. Ketamine has given her "herself" back. I haven't seen her like this since she was a child. I'm so thankful she found two wonderful doctors who provided such a wonderful and amazing medicine.